Rheumatoid Arthritis (RA) is a common autoimmune disease affecting 0.5-1.0% of adults. RA is characterised by chronic inflammation of the synovium which can lead to joint destruction and disability.1 The most frequent test for RA is the measurement of rheumatoid factor (RF).2 Although the RF test has good sensitivity, it is not specific for RA. Anti-CCP antibodies have been found to be present very early in RA, often with the absence of clinical symptoms and many reports indicate that elevated levels of anti-CCP antibodies can predict the development of erosive disease.3,4,5.
Axis-Shield Anti-CCP EIA
The Axis-Shield Anti-CCP test is a semi-quantitative/qualitative ELISA for the detection of the IgG class of autoantibodies specific to cyclic citrullinated peptide (CCP) in human serum or plasma. Detection of anti-CCP antibodies is used as an aid in the diagnosis of Rheumatoid Arthritis (RA) when used in conjunction with other clinical information.
The Anti-CCP EIA is a microtitre plate ELISA method. Each kit is supplied with a 96-well microtitre plate with breakapart strips and all required reagents, calibrators and controls. Readily adaptable to ELISA liquid-handling automates. Absorbance is measured at 450nm. CE-marked and 510(k)-cleared. Available in 15 languages.
- Feldmann M, Brennan FM, Maini RN. Rheumatoid Arthritis. Cell 1996;85:307-10.
- Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31(3):315-24.
- Rantapaa-Dahlqvist S, de Jong BA, Berglin E, et al. Antibodies against cyclic citullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthirtis Rheum 2003: 48(10):2741-49
- Nielen MM, van Schaardenbur D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis. Arthritis Rheum 2004: 50 (2):380-386
- van Gaalen, Linn-Rasker SP, van Venrooij WJ, et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis. Arthritis Rheum 2004: 50(3):709-15
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