Syphilis is a venereal disease caused by Treponema pallidum. As this organism cannot be cultured, the specific antibodies demonstrated by serological tests are important. The TPI and FTA-ABS serological tests present difficulties for routine serodiagnosis as both tests require a high level of expertise. TPHA assays are a convenient and specific test for the diagnosis of treponemal infection, with specificity similar to the TPI test1 and sensitivity comparable to the FTA-ABS test2. It requires minimal laboratory equipment and is very simple to perform.
Axis-Shield MICROSYPH TPHA
MICROSYPH TPHA is a rapid assay for the detection of specific antibodies to Treponema pallidum in human serum or plasma by indirect haemagglutination. FTPHA200 and FTPHA500 kits may be used for semi-quantitative titration of positive samples. FTPHA1000 is intended to be used as an initial screening test.
- The MICROSYPH test contains the following components:
- Sensitised TPHA Test Cells
- Sample Diluent (featuring Sample addition Monitor)
- TPHA positive and negative serum controls
- FTPHA200 and FTPHA500 kits also contain control cells.
- Assay time is 45-60 minutes.
- Instruction leaflet in multiple languages
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- Sequeira, P.J.L. et al (1973). Treponemal haemagglutination test. Brit. J. Vener. Dis., 49, 242.
- Johnston, N.A. (1972). Treponema pallidum haemagglutination test for syphilis. Evaluation of a modified micro-method. Brit.J.Vener.Dis., 48, 474.
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